Senior Research Associate - Structural and Chemical Biology in San Diego, CA at Apex Life Sciences

Date Posted: 10/31/2018

Job Snapshot

Job Description


Summary/Scope: 

  • The Structural and Chemical Biology department has an exciting opportunity for a Senior Associate Scientist in cell signaling and protein degradation.
  • We are seeking an experienced and self-motivated individual to help our team design and analyze the activity of a library of engineered proteins using biochemical and/or cell-based strategies. 

Responsibilities will include, but are not limited to, the following: 

  • Development and implementation of biochemical assays using purified proteins and extension of these assays to high-throughput formats. 
  • Development and implementation of cell-based assays to assess protein/protein interactions and the activity of signaling pathways. 
  • Analysis of structure and activity relationships in engineered proteins. 
  • Recombinant protein expression and purification from bacteria. 
  • Clearly communicate results/data at project team meetings. 
  • Maintaining an accurate and well-organized scientific notebook. 

Skills/Knowledge Required: 

  • Optimization and analysis of complex cell-based and/or biochemical and enzyme assays. 
  • Experience with methods to interrogate protein/protein interactions in vitro, including HTRF and AlphaLISA, is highly desireable. Knoweledge of other high-throughput screening technologies a plus. 
  • Construct design and protein expression in bacteria. 
  • Knowledge of protein purification strategies (i.e. affinity, ion-exchange, SEC) and the use of AKTA purifiers. 
  • Common methods for the analysis of purified proteins including SDS-PAGE and western blotting. 
  • Preparation of human tissue culture extracts and their anaylsis using western blotting and other standard molecular techniques. Experience with human tissue culture a plus. 
  • Experience interrogating small molecule-protein interactions. 

Prerequisites: 

  • Bachelor’s degree in a scientific discipline with at least 8 years work experience or Master’s degree with at least 6 years work experience.

Please send resumes to khurlbut@apexlifesciences.com

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EEO Employer

Apex is an Equal Employment Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, age, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. Apex will consider qualified applicants with criminal histories in a manner consistent with the requirements of applicable law. If you have visited our website in search of information on employment opportunities or to apply for a position, and you require an accommodation in using our website for a search or application, please contact our Employee Services Department at 844-463-6178.




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