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Scientist I in San Francisco, CA at Apex Life Sciences

Date Posted: 11/27/2018

Job Snapshot

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Job Description

Apex Life Sciences is seeking a talented and motivated drug discovery Scientist who will support small molecule discovery using mass spectrometry. This is a direct hire opportunity, full time from Monday - Friday, 1st shift.


Youwill develop and implement affinity selection mass spectrometry (ASMS) methods as part of hit validation from our DNA Encoded Library and Virtual Screening platforms to rapidly access chemical matter that modulates targets within the ubiquitin proteome system (UPS). You will use your strong understanding of protein biochemistry to inform the development of assays to assess novel protein-small molecule and protein-protein interactions.

As a member of a dynamic multi-disciplinary project team, you will collaborate with a broad group of scientists within the company as well as with external collaborators. You should have a strong desire to learn new techniques and incorporate new methodologies into your work. You must be self-driven, resourceful, organized and focused, and enjoy being a part of a dynamic team in a project-based environment solving challenging scientific problems to benefit patients.


  • Ph.D. in chemistry, biochemistry, biology or another relevant life science.
  • Expertise in mass spectrometry techniques; relevant training with ASMS is especially desired.
  • Experience with operation, troubleshooting and maintenance of qTOF and sQ mass spectrometers and associated separation techniques (LC, SEC, SPE)
  • Familiarity with intact mass protein MS, and characterization of protein-small molecule adducts
  • Experience with the execution of biochemical and/or biophysical assays for evaluation of small molecule modulators.
  • Desire to lead initiatives in platform building and technology development.
  • Solid track record of scientific accomplishment demonstrated by publications, patents, or presentations.
  • Excellent communication skills and able to present the rationale, key data, issues and accomplishments in a matrix setting.

Secondary but desirable qualifications:

  • Familiarity with spreadsheet management and software such as Spotfire and DotMatics
  • Understanding of principles and practice of DNA encoded library technology
  • Expertise in interrogating biochemical mechanism of action, especially for proteins of the UPS

If interested, please apply with an updated resume or send directly to Nancy at for immediate consideration!

EEO Employer

Apex is an Equal Employment Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, age, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. Apex will consider qualified applicants with criminal histories in a manner consistent with the requirements of applicable law. If you have visited our website in search of information on employment opportunities or to apply for a position, and you require an accommodation in using our website for a search or application, please contact our Employee Services Department at 844-463-6178.