Research Associate II/ Senior RA, Cell Culture in Waltham, MA at Apex Life Sciences

Date Posted: 11/2/2018

Job Snapshot

Job Description


Job Scope & Purpose:  

Our growing biotech client is looking for a highly motivated and talented Researcher with expertise in Antibody discovery and preferably an Immuno-oncology background to join their Biologics discovery team. In this role, you will make significant contributions to the discovery of biotherapeutic cancer therapies using a novel immune-oncology (NK/T-cell) platform. You should come in with proven ability to independently initiate and follow through on new projects.  The successful candidate will participate as a thoughtful member of the Biologics Research team and specialize in transient and stable transfection, with stable CHO cell lines and subsequent selection for lead candidates.  Hands-on expertise with bioprocess for mammalian cell culture for bi-specific or multi-specific in your role. If you are interested reach out to Chris Clancy and the R&D placement team today to learn more!

Primary Job Responsibilities: 

  • Develops robust mammalian cell culture bioprocess for a range of multi-specific antibodies of multiple scaffolds in shaker flasks, SUBs and wave bioreactors

  • Techniques with characterization including Batch and Fed-batch evaluation, and other characterization of cell lines

  • Ability to evaluate media and feed components to optimize titers

  • Participate in team efforts in sequence analysis, cloning, vector construction, and other molecular biology activities

  • Hands-on experience in standard molecular biology skills including bacterial culture & transformation, PCR, molecular cloning, DNA purification, restriction digestion, seq. analysis, and vector construction

  • Knowledge of stable GMP cell line generation and experience working with CROs is a plus

  • Knowledge of cloning methods including Gibson cloning, retro/lentiviral-mediated transduction, a plus

  • Ability to record and report findings under ELN systems under protocols in accordance with regulatory filings

Primary Job Qualifications:

  • B.S with 5+ years of industry experience in mammalian cell culture and upstream optimization
  • Extensive hands-on experience in mono- and bispecific antibody, scFV, antibody-fusion generation using transient ExpiCHO, Expi293, stable CHO pools and lines

  • Must have hands-on experience with wave bioreactors

  • Excellent aseptic skills and mammalian cell culture experience is a must

  • Proven ability to achieve high titers by process optimization and media and feed optimization

  • Strong interpersonal skills and ability to effectively communicate with a multidisciplinary team

  • The ability to work collaboratively, provide strategic input, communicate clearly both written and orally is critical for success in this position 

About Stratacuity:

Whether you are seeking a career change or simply interested in becoming part of our network, you will appreciate the ethics guiding each Stratacuity team member. We build lasting relationships with exceptional biopharmaceutical talent and take great care to protect your personal information. Upon receiving your inquiry, you may be directly contacted by a Stratacuity team member to discuss your career goals. We will not share your information with anyone without your direct prior consent.

PROVEN SCIENTIFIC PLACEMENT™

Stratacuity is an Equal Employment Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, age, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. Stratacuity will consider qualified applicants with criminal histories in a manner consistent with the requirements of applicable law. If you have visited our website in search of information on employment opportunities or to apply for a position, and you require an accommodation in using our website for a search or application, please contact us at info@stratacuity.com or 877-787-2821.

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EEO Employer

Apex is an Equal Employment Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, age, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. Apex will consider qualified applicants with criminal histories in a manner consistent with the requirements of applicable law. If you have visited our website in search of information on employment opportunities or to apply for a position, and you require an accommodation in using our website for a search or application, please contact our Employee Services Department at 844-463-6178.

EEO Employer

Apex is an Equal Employment Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, age, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. Apex will consider qualified applicants with criminal histories in a manner consistent with the requirements of applicable law. If you have visited our website in search of information on employment opportunities or to apply for a position, and you require an accommodation in using our website for a search or application, please contact our Employee Services Department at 844-463-6178.




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