Research Associate, Cell Biology in Summit, NJ at Apex Life Sciences

Date Posted: 8/29/2018

Job Snapshot

  • Employee Type:
    Full-Time
  • Location:
    Summit, NJ
  • Job Type:
  • Experience:
    Not Specified
  • Date Posted:
    8/29/2018
  • Job ID:
    882011

Job Description


Research Scientist- Cell Biology


BASIC RESPONSIBILITIES: 

  • Possesses a strong understanding of science behind ongoing experiments
  • The scientist displays initiative in learning new techniques and research approaches and communicates results to supervisors and teams. 
  • Scientist specializing in cell and molecular biology supporting Translational Research by mechanism-of-action studies and defining biomarker strategies.
  • Contributions involve expertise in enzyme and cell-based assays to the application of protein and nucleic acid technologies.
  • Participates in activities such as vector design and generation, transient and stable cell transfection & transduction and cell-based functional assays.
  • Experience with primary cell culture, co-cultures, flow cytometry and inducible gene silencing are a plus.
  • Contractor will have basic knowledge of oncogenic/immunological signaling pathways and actively follows the scientific literature.
  • The contractor will use cutting-edge techniques to address questions of drug mechanism of action, differentiation and resistance using primarily in vitro models.
  • Will be responsible for well-defined and controlled experiments being mindful of translational relevance.
  • Responsible for experimental design, troubleshooting and interpretation of results.

SPECIFIC DUTIES: 

  • Assay development to support biomarker strategies for clinical trials 
  • Develop in-vitro assays for evaluating mechanisms of drug resistance, drug differentiation and pharmacodynamic marker identification (develop resistant cell lines, make stable and conditional knock-downs and knock-ins, cellular trafficking studies) 
  • Study the intracellular signaling networks and feedback mechanisms within pertinent cell types to assess mechanism of action and rationalize drug combination strategy. 
  • Interface with bioinformaticians to analyze genomics data for understanding pathways of resistance and differentiation of drugs in development 
  • Ensures that the Translational Development Department maintains current awareness in area of expertise, enhances the scientific credibility of through contributions to the scientific literature (publications/presentations), through extramural activities and scientifically related interactions with academics 
  • Assumes responsibility for writing non-clinical pharmacology study reports, invention disclosures, and contribute to the writing of investigator brochures, IND applications, regulatory annual reports, and other regulatory documents when appropriate. 

The position requires an individual with: 

  • A MS or BS degree in a field of cell biology, biochemistry or molecular biology
  • 5-7 years hands-on research experience.
  • Experience in drug discovery, oncogenic and immune cell signal transduction and translational medicine is a plus. 

Skills/Knowledge Required: 

  • ACCOUNTABITY: 
    • The position is responsible for planning and executing research plans in the defined area of investigation.
    • This position has responsibility for the quality, quantity, timeliness, and scientific acceptability of translational development activities that support early drug development. 
  • EXTERNAL: 
    • Moderate contact with CROs and laboratories, universities and appropriate professional groups as necessary.

For immediate Consideration: Send your resume to grucci@apexlifesciences.com with 'Cell Biology' in the subject line. 

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EEO Employer

Apex is an Equal Employment Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, age, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. Apex will consider qualified applicants with criminal histories in a manner consistent with the requirements of applicable law. If you have visited our website in search of information on employment opportunities or to apply for a position, and you require an accommodation in using our website for a search or application, please contact our Employee Services Department at 844-463-6178.




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