Research and Development Associate III in Durham, NC at Apex Life Sciences

Date Posted: 5/29/2018

Job Snapshot

  • Employee Type:
  • Location:
    Durham, NC
  • Job Type:
  • Experience:
    Not Specified
  • Date Posted:
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Job Description

Apex Life Sciences is seeking qualified candidates for a Research and Development Associate III position in RTP!

Provide expertise in next generation sequencing (NGS) and in the application of NGS-related technologies to support efforts to expand the use of NGS capabilities for genotyping and other traditionally PCR-based applications. 

Accountabilities include: 
• Evaluation of new methods to enable the application of next generation sequencing (NGS) to higher throughput, lower cost applications (e.g., cheaper library prep, new approaches to DNA concentration normalization, etc.). 
• Provide data analysis and management expertise for NGS applications and to support prototype tool development within the broader Biology Technology function. Customize reporting format as needed. 

Critical knowledge 
• Ph.D., or a Master's degree with 3+ years of professional experience, in Molecular Biology, Plant Biochemistry, Bioinformatics, or related field. 
• A strong understanding of NGS: fundamentals, critical factors influencing data quality, and an ability to troubleshoot the sequencing process end to end. 
• Experience with commercial tools for analysis of NGS data, and an understanding of scripting (in Unix or other relevant platform) required for analysis of NGS and other ?big data”. 
• Knowledge of R. 
• Techniques in molecular biology including DNA extraction and purification, PCR and qPCR, DNA library preparation, etc. 

Critical experience 
• 3+ years of hands-on experience maintaining and running next-generation sequencing instruments, including at least Illumina sequencers. The ideal candidate would also have experience with other NGS platforms such as Ion Torrent, Oxford Nanopore, PacBio, etc. 
• Expertise in the analysis and management of NGS and other “big data”. 
• Demonstrated expertise in molecular biology wet lab skills including DNA extraction and purification from diverse tissue samples, DNA library preparation, etc. 
• Experience with optimization of wet lab techniques to improve sequencing data quality, robustness, etc. 

Critical technical, professional and personal capabilities 
• Strong scientific background in molecular biology and next generation sequencing technology, with experience managing and analyzing large data sets. 
• Skill sets in Bioinformatics and relevant tools. 
• Team player with the ability to successfully integrate and cultivate an effective and innovative team environment across disciplines, sites and cultures. 
• Project management knowledge to successfully navigate a complex technical and matrix environment. 
• Ability to work effectively in a cross-functional, multi-site, multi-cultural, cross-business environment; must be able to deal with complexity, some ambiguity and maintain focus on essential activities. 
• National and international travel on infrequent basis. 
• Excellent oral and written communication skills. 
• Independence and ability to manage self. 

Beneficial expertise, but not critical 
• Experience translating methods from the laboratory to a routine pipeline. 
• Experience with multivariate approaches and tools (Design of Experiments, JMP-SAS, etc.) for method development and process optimization. 

• Management/maintenance of sequencing and related equipment used by Molecular Analytics. 
• Support testing of novel methods for genotyping involving NGS as well as more traditional PCR-based approaches. 
• Provide in-house support for continuing efforts towards rare variant detection using NGS. 
• Provide subject matter expertise on NGS projects. 

We are looking for someone with expertise/experience with next-generation sequencing platforms, as well as with the use of computational tools to analyze sequencing and other 'big data'. This person will work with a senior scientist, but will be expected to operate independently. 

Looking for someone with a recent PhD (with this job somewhat like a post-doc), or with a Masters plus several year’s experience.