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Principal Scientist/Senior Scientist - Antibody Engineering in San Carlos, CA at Apex Life Sciences

Date Posted: 12/11/2018

Job Snapshot

Job Description

What Will You Be Doing?

  • Engineering antibodies to maximize their therapeutic potential
  • Working collaboratively with project team leaders to obtain a working knowledge of various therapeutic targets and participate in structural decisions to facilitate therapeutic antibody generation (humanization, Fc receptor engineering using mutation or altered glycosylation, hypermutation strategies to optimize PK or target binding)
  • Working closely with biologists to further optimize lead antibody characteristics (Fc-mediated effector function, PK) using data generated from appropriate cell-based assays and preclinical animal models.
  • Applying deep sequencing (NGS) and bioinformatics for antibody engineering and repertoire analysis
  • Optimizing affinity, molecular cloning and sequencing analysis, protein production, stability, purification and characterization strategies

Why Work with Us?

  • Competitive compensation and benefits package
  • Performance bonus
  • Collaborative work environment emphasizing professional growth and development
  • Strong positive company culture in a highly collaborative environment

What You Need for this Position


  • Ph.D. in Biological Science (molecular biology, structural biology, protein chemistry)
  • Minimum of 3 years of industry experience in antibody engineering space
  • In-depth knowledge of state-of-the-art technologies and methods for design and optimization of antibody-based therapeutics
  • Strong molecular biology skills
  • Strong track record of success demonstrated through publications in highly regarded journals and/or intellectual property generation
  • MUST have prior hands-on experience humanization/Fc engineering
  • Knowledge of hybridoma, B-cell cloning and sequencing, phage display are a definite plus
  • Experience outsourcing and managing projects with CROs is useful but not required

If you feel like you would be a good fit for this position, please email your resume to

EEO Employer

Apex is an Equal Employment Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, age, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. Apex will consider qualified applicants with criminal histories in a manner consistent with the requirements of applicable law. If you have visited our website in search of information on employment opportunities or to apply for a position, and you require an accommodation in using our website for a search or application, please contact our Employee Services Department at 844-463-6178.