Lead Scientist - Enzyme Engineering in San Diego, CA at Apex Life Sciences

Date Posted: 3/23/2018

Job Snapshot

Job Description

Our client, a biotech start-up, is seeking a Lead Scientist with experience in Enzyme Engineering. 

Job Description

  • Plan and carry out experiments, analyze results, present findings, solve challenging technical problems
  • Design and optimize DNA sequencing methods using novel chemistries
  • Formulate and optimize critical reagents to be used with polymerases.
  • Carry out experimental work involving DNA/enzyme manipulation with an emphasis on quantitative analysis of results.
  • May use advanced techniques of fluorescence microscopy to push the boundaries of DNA sequencing performance (accuracy, read length, throughput)
  • Work closely with other members of the R&D team, with expertise in organic chemistry, surface chemistry, enzyme engineering, enzyme purification and application, physics, micro-fluidics, optics, signal processing and engineering.


  • PhD in Molecular Biology, BioChemistry, BioPhysics or related field
  • 6+ years R&D experience, post-PhD
  • Very strong quantitative analytical and experimental skills, and deep physical insights
  • Experience in Enzyme Kinetics, especially kinetics of DNA polymerases including measurement of all relevant kinetic parameters.
  • Apply quantitative methods to molecular biology methods including amplification.
  • Specific expertise in protein engineering by extensive mutagenesis. 
  • Able to use existing crystallographic and sequence data to identify likely mutagenesis targets to improve DNA polymerase for novel nucleotides.
  • Demonstrated ability to come up with innovative ideas and develop them into commercial applications and intellectual property
  • Desire and ability to work in a small interdisciplinary team to develop new technologies at a rapid pace
  • Experiences preparing and running mutagenesis and screening pipelines.
  • Next-Gen sequencing experience a plus.


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