Bench Scientist I in South San Francisco, CA at Apex Life Sciences

Date Posted: 8/29/2018

Job Snapshot

Job Description

Apex Life Sciences is seeking a Scientist skilled in mass spectrometry (MS) in the South San Francisco area! Our client's Cancer Immunology Discovery Unit (CID), located in South San Francisco, is a pioneer in antibody based therapeutics.


  • The selected candidate will perform MS-based antibody de novo sequencing and/or proteomics analysis, as well as antibody intact analytical characterization.
  • To succeed, you will need to be an enthusiastic team player, detail-oriented, extremely organized and comfortable working on complex problems.
  • This is a hands-on bench position, focused on sample preparation, MS data acquisition, instrument maintenance/troubleshooting and data analysis.
  • This candidate should have the ability to independently plan, design, and implement protocols to successfully solve issues related to protein characterization and de novo sequencing.
  • The individual will be responsible for the whole workflow from sample preparation to data analysis.
  • Perform sample preparations including antibody digestions for peptide mapping analysis, and assist the fluorochromes labeling preparation for flow cytometry
  • De novo sequence and analyze intact and subunit of Ab using state of the art MS techniques and software
  • Maintain and troubleshoot Thermo Orbitrap mass spectrometers and nano-LC systems
  • Support the recombinant Ab expressions and purifications with AKTA systems
  • Maintain excellent documentation of all work including laboratory notebooks, test methods, or any other appropriate documents.
  • Write and review internal reports, in addition to presenting results and experimental information to departmental colleagues


  • PhD in analytical chemistry, biochemistry or related scientific fields or master with 3 years of industrial experience in proteomics and/or monoclonal antibody characterization
  • Hands-on experience in sample preparation including peptide mapping, antibody purification and labeling
  • 2+ years of experience in proteomics and intact protein analysis on Thermo Q Exactive Series and LTQ Orbitrap Velos mass spectrometers equipped with Flex Ion Source is strongly preferred
  • Experience in maintaining and troubleshooting Agilent and Dionex nanoflow UPLC and mass spectrometers
  • Experience with recombinant antibody purification with AKTA system is desired but not required
  • Strong communication skills and exemplary attention to detail

EEO Employer

Apex is an Equal Employment Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, age, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. Apex will consider qualified applicants with criminal histories in a manner consistent with the requirements of applicable law. If you have visited our website in search of information on employment opportunities or to apply for a position, and you require an accommodation in using our website for a search or application, please contact our Employee Services Department at 844-463-6178.